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PrEP and TasP¨ modelling shows need for optimization

Gay, bisexual and other men who have sex with men (MSM) have been disproportionally affected by the HIV epidemic in British Columbia (BC). Since 2010, Treatment as Prevention®¨ (TasP®¨) has been adopted as a public health policy in BC to maximize health care engagement of people living with HIV and improve virologic suppression, and as a result, to reduce secondary new infections. However, TasP®¨ has been relatively less responsive in reducing HIV transmission among MSM than in other populations in BC, which calls for further optimization and combination with other preventive strategies.

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BC-CfE research explores antibody response to COVID-19 vaccine among LTC residents

The BC-CfE’s Laboratory Director Dr. Zabrina Brumme alongside Dr. Mark Brockman of Simon Fraser University and Dr. Marc Romney of Providence Health Care and UBC co-led research which found that a single dose of the Pfizer-BioNTech COVID-19 vaccine produces a much weaker antibody response inlong-term care (LTC) residents than it does in younger healthy adults.

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BC-CfE researches understudied gbMSM subgroup’s cardiovascular health

A BC-CfE-led team of interdisciplinary researchers recently published their work in the Canadian Journal of Human Sexuality examining the cardiovascular health of an understudied subgroup among gay, bisexual and other men who have sex with men (gbMSM)-“Assessing Bear/Cub/Otter identity and history of cardiovascular disease among gay, bisexual, and other men who have sex with men in Metro Vancouver“

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BC-CfE research provides real-world data on efficacy of generic cART

First introduced in the mid-1990s through the pioneering work of BC-CfE Executive Director and Physician-in-Chief Dr. Julio Montaner, combination antiretroviral therapy (cART) is a pillar of the Treatment as Prevention®¨ strategy that has enabled people living with HIV to live longer and healthier lives and has dramatically reduced the risk of HIV transmission.

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BC-CfE research on coronavirus evolution helps in vaccine design and deepens understanding of viral mutations

The BC-CfE continues to lead the way in COVID-19 research, with the latest published research on the topic coming from the Centre’s Molecular Epidemiology and Evolutionary Genetics Group.

The paper, which features contributions from almost all members of the group, focuses on evolutionary patterns among coronaviruses that have jumped from animal hosts into humans and is titled “Variable routes to genomic and host adaptation among coronaviruses“.

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BC-CfE researchers collaborate to determine impact of COVID-19 vaccines in residents of long-term care facilities in BC

BC-CfE researchers are working alongside colleagues from the University of British Columbia, Providence Health Care, and Simon Fraser University to investigate how elderly peoples’ immune systems respond to COVID-19 vaccines. The researchers will also assess the viral, immunological and social factors that have contributed to COVID-19 outbreaks in long-term care facilities in order to better understand why and how the disease has been fatal to so many residents.

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BC-CfE researchers examine aging and comorbidities in people living with HIV

Thanks to the introduction of highly active antiretroviral therapy (HAART) in the 1990s and the BC-CfE’s Treatment as Prevention®¨ strategy, people living with HIV (PLWH) in BC are now able to live longer lives. With an increased lifespan, morbidity and mortality from non-AIDS comorbidities have emerged as major concerns.

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The BC-CfE Laboratory is streamlining reporting processes for certain tests in order to simplify distribution and record-keeping, and to ensure completeness of results. Beginning September 2, 2025, results for the ‘Resistance Analysis of HIV-1 Protease and Reverse Transcriptase’ (Protease-RT) and ‘HIV-1 Integrase Resistance Genotype’ tests will be combined into a single ‘HIV-1 Resistance Genotype Report’.
For more details and example reports, please click on the button below