Chinese scientists together with US experts have determined the high-resolution structure of one of two gateways HIV uses to get into the human immune system, which could help develop better HIV drugs in the future.
The research was led by scientists from Shanghai Institute of Materia Medica under the Chinese Academy of Sciences, and the study result was published in the peer-reviewed journal, Science.
CCR5, a receptor on the surface of human cells, is one of two main entry points the HIV virus uses to initiate its attack on the human immune system. By binding to the receptor, an HIV protein can fuse to the cell membrane beneath, ultimately digging its way inside the cell.
Both CCR5 and CXCR4 belong to a family of proteins called G-protein-coupled receptors, or GPCRs, which mediate a range of functions in the body and are thus important drug targets.
Wang Hongyi in Shanghai
China Daily
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