Laboratory

Nef gene function and HIV subtype influence viral reservoir size

In patients with human immunodeficiency virus (HIV), the size of the viral reservoir depends, at least in part, on their HIV subtype and the level of Nef gene activity, researchers say. Although current HIV therapies can suppress the virus and prevent transmission to sexual partners, they are not yet able to eliminate the HIV reservoir […]

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Top SFU News stories of 2018

Being named Canada’s top comprehensive university for the 10th time in 11 years capped an electrifying 2018 at SFU. This past year saw the arrival of the university’s two Canada 150 chairs as well as the high-profile joint-conferral (with UBC) of an honorary doctorate of laws degree on His Highness the Aga Khan. Here’s a

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Genotypic and Mechanistic Characterization of Subtype-Specific HIV Adaptation to Host Cellular Immunity

Can you provide a brief overview of your lab’s current research focus? The Brumme laboratory at SFU and the BC Centre for Excellence in HIV/AIDS integrates molecular biology, epidemiology and computational approaches to examine questions at the interface of HIV virology, immunology and pathogenesis with the ultimate goal of preventing and curing HIV infection. What

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Human Resources & Education For the record, September 4, 2018

HEALTH/MEDICAL Dr. Zabrina Brumme has been appointed director at the BC Centre for Excellence in HIV/AIDS, Canada’s leading HIV laboratory program. Brumme will be on secondment from her position as associate professor in the faculty of health sciences at Simon Fraser University (SFU); she joined SFU in 2009 as assistant professor, molecular epidemiology of infectious

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B.C. researchers identify multiple strains of HIV ‘time bombs’ hibernating in cells

B.C. researchers have discovered a way to identify multiple strains of HIV that lay dormant in the cells of an individual. HIV evolves continually while it is active, storing versions of itself in the DNA of infected cells that then go dormant, waiting to reactivate at some future date, like an archive of genetically unique

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Why has HIV in Saskatchewan become more harmful for some people?

Reports have suggested that HIV may be progressing more rapidly in Saskatchewan. Researchers analyzed the genetic sequences of HIV among people in the province. They discovered strains of HIV that have adapted to some people’s immune defences. The immune system consists of a network of cells, tissues and organs, all organized to help defend the

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