Researchers reflect on three decades of HIV research

It has been 35 years since the first case of HIV/AIDS was recorded in Connecticut, and since then, Yale has been at the forefront of scientific interventions to address the challenges posed by the epidemic.

Elaine O’Keefe, who currently serves as the executive director for Yale’s Center for Interdisciplinary Research on AIDS, was one of the first public health practitioners to work on the epidemic. She vividly recalls the grave circumstances brought upon certain New Haven residents by the advent of HIV/AIDS in the 1980s.

“New Haven was the epicenter of HIV in Connecticut at the time,” she said. “HIV was heavily impacting the gay community and devastating injection drug users.”

Then working as a staffer in the New Haven health department, O’Keefe implemented the first legal needle exchange program in the United States with the help of her colleagues – and critical assistance from Yale researchers.

“There were people at Yale even then who were very committed not only to helping us with our organizing effort, but also to evaluating the syringe exchange program and showing that it was effective,” O’Keefe said, speaking in an office decorated with photos of the original needle-exchange van that she and her colleagues had set up three decades ago. “Their work remains today as one of the most substantial contributions made in the field of HIV prevention and treatment.”

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During the Canada Post strike announced September 25, 2025, the following measures will be undertaken to minimize service disruption to BC-CfE clients and providers.

  • The BC-CfE Laboratory has transitioned to private courier for delivery of outgoing reports and documents. Results required urgently can be faxed upon request. (Lab Contact Information: Phone 604-806-8775; FAX 604-806-9463)
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During the Canada Post strike, we recommend that documents be faxed or couriered to our sites, versus utilization of regular mail service

The BC-CfE Laboratory is streamlining reporting processes for certain tests in order to simplify distribution and record-keeping, and to ensure completeness of results. Beginning September 2, 2025, results for the ‘Resistance Analysis of HIV-1 Protease and Reverse Transcriptase’ (Protease-RT) and ‘HIV-1 Integrase Resistance Genotype’ tests will be combined into a single ‘HIV-1 Resistance Genotype Report’.
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