HIV Patients With Cancer Pose Tx Challenge

published on September 12, 2013 in MedPage Today

DENVER -- HIV patients with cancer should avoid antiretroviral therapy based on protease inhibitors (PIs) if possible, a researcher said here.

In a retrospective analysis, patients on a PI-based regimen had more side effects and were less likely to maintain anti-HIV efficacy 6 months after diagnosis, according to Harrys Torres, MD, of the MD Anderson Cancer Center in Houston.

On the other hand, patients taking a regimen based on either an integrase inhibitor (INSTI) or and non-nucleoside reverse transcriptase inhibitor (NNRTI) had fewer adverse events and better efficacy, Torres reported here at the annual Interscience Conference on Anti-Microbial Agents and Chemotherapy.

The issue is important, Torres said, because non-AIDS defining malignancies have been an increasing issue among HIV patients and now account for about 33% of all HIV-related deaths. Despite that, he said, there is little evidence pointing to the best HIV regimen for such patients.

To help clarify the issue, he and colleagues looked at the safety and efficacy of various HIV regimens among men who were treated for both cancer and HIV at MD Anderson over a 12-year period.

Michael Smith
MedPage Today
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© Copyright BC Centre for Excellence in HIV/AIDS
St. Paul's Hospital 608–1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
Tel: 604-806-8477 | Fax: 604-806-9044
General inquiries: info@bccfe.ca
Media inquiries: communications@bccfe.ca
(Please do not use any of these email addresses to send personal information or book an appointment. To book appointments or contact the H2H clinic, please call 604-416-1517 or fax: 604-564-4893. Do not send your or your client's personal information via email.)

Our work serves clients and communities across British Columbia on lands and waters cared for and nurtured by the many distinct First Nations across the province. The BC-CfE humbly and gratefully acknowledge the stewards of these lands, particularly the xʷməθkʷəy̓əm (Musqueam), Sḵwx̱wú7mesh (Squamish), and səl̓ílwətaʔ (Tsleil-Waututh) on whose unceded, traditional and ancestral territories our offices are located.