Early Tx for Infants with HIV Beats Waiting

published on August 21, 2013 in MedPage Today

For neonates with HIV, early treatment followed by a drug holiday yielded better results than deferring treatment until it was medically necessary, researchers reported.

In a randomized, open-label study, children in the programmed therapy interruption arms were significantly less likely to die or to have treatment failure than those on deferred therapy, according to Mark Cotton, MD, PhD, of Stellenbosch University in Tygerberg, South Africa.

They were also significantly less likely to have HIV disease progression, Cotton and colleagues reported online in The Lancet.

The so-called CHER (children with HIV early antiretroviral) trial enrolled infants with HIV but without symptoms and randomly assigned them to deferred treatment or to therapy for either 40 or 96 weeks, after which it would be stopped until starting again became medically necessary.

Michael Smith
MedPage Today
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© Copyright BC Centre for Excellence in HIV/AIDS
St. Paul's Hospital 608–1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
Tel: 604-806-8477 | Fax: 604-806-9044
General inquiries: info@bccfe.ca
Media inquiries: communications@bccfe.ca
(Please do not use any of these email addresses to send personal information or book an appointment. To book appointments or contact the H2H clinic, please call 604-416-1517 or fax: 604-564-4893. Do not send your or your client's personal information via email.)

Our work serves clients and communities across British Columbia on lands and waters cared for and nurtured by the many distinct First Nations across the province. The BC-CfE humbly and gratefully acknowledge the stewards of these lands, particularly the xʷməθkʷəy̓əm (Musqueam), Sḵwx̱wú7mesh (Squamish), and səl̓ílwətaʔ (Tsleil-Waututh) on whose unceded, traditional and ancestral territories our offices are located.