Computer models that predict response to treatment

published on September 14, 2011 in News Medical

Details of computer models that can predict the chances of a patient responding to their HIV drugs with 80% accuracy are published today in the journal AIDS. The models were developed by the HIV Resistance Response Database Initiative (RDI) using almost half a million pieces of data from approximately 6,000 clinical cases from hundreds of clinics around the world. The models are now available online as part of an experimental treatment support tool, HIV-TRePS.

The random forest models were trained to predict the probability of any combination of HIV drugs reducing the virus in the patient’s blood to an undetectably low level (<50 copies/ml). They use the genetic code of the virus, the patient’s immune status, their treatment history and a measure of the level of HIV in the blood, to make their predictions.

“The publication of these results is an important milestone in the development of expert computer systems to aid clinical practice”, commented Professor Julio Montaner, etc. “The models harness the experience of hundreds of physicians treating thousands of patients and puts this distilled expertise in the hands of the individual physician via the click of a mouse.”

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© Copyright BC Centre for Excellence in HIV/AIDS
St. Paul's Hospital 608–1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
Tel: 604-806-8477 | Fax: 604-806-9044
General inquiries: info@bccfe.ca
Media inquiries: communications@bccfe.ca
(Please do not use any of these email addresses to send personal information or book an appointment. To book appointments or contact the H2H clinic, please call 604-416-1517 or fax: 604-564-4893. Do not send your or your client's personal information via email.)

Our work serves clients and communities across British Columbia on lands and waters cared for and nurtured by the many distinct First Nations across the province. The BC-CfE humbly and gratefully acknowledge the stewards of these lands, particularly the xʷməθkʷəy̓əm (Musqueam), Sḵwx̱wú7mesh (Squamish), and səl̓ílwətaʔ (Tsleil-Waututh) on whose unceded, traditional and ancestral territories our offices are located.