Symptomatic elevations of lactic acid and their response to treatment manipulation in HIV infected individuals – A case series

2001 | Clinical Infectious Diseases

http://www.ncbi.nlm.nih.gov/pubmed/11712096

Abstract:

Symptomatic lactic acidemia was seen in 5 human immunodeficiency virus-positive patients receiving combination therapy that included stavudine and > or =1 other nucleoside. Peak venous lactic acid levels of 3.1-7.4 mmol/L (normal range, 0.5-2.1 mmol/L) were associated with fatigue and rapid weight loss, whereas withdrawal of antiretrovirals led to normalization of venous lactic acid levels, symptomatic improvement, and weight gain. Resumption of an altered therapeutic regimen, which did not include stavudine but did include other nucleosides in 4 of 5 cases, did not result in recurrence of the syndrome after up to 126 days.

Text or Node

Delgado J

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Symptomatic elevations of lactic acid and their response to treatment manipulation in HIV infected individuals – A case series

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