Recent abacavir use increases risk for Types 1 and 2 myocardial infarctions among adults with HIV.

2018 | J Acquir Immune Defic Syndr.

Program(s): Epidemiology and Population Health |
Initiative(s): COAST |

Abstract:

BACKGROUND:

There is persistent confusion as to whether abacavir (ABC) increases the risk for myocardial infarction (MI), and whether such risk differs by Type 1 (T1MI) or 2 (T2MI) MI in adults with HIV.

METHODS:

Incident MIs in NA-ACCORD participants were identified from 2001 to 2013. Discrete time marginal structural models addressed channeling biases and time-dependent confounding to estimate crude (HR) and adjusted hazard ratios (aHR) and 95% confidence intervals; analyses were performed for T1MI and T2MI separately. A sensitivity analysis evaluated whether Framingham Risk Score (FRS) modified the effect of ABC on MI occurrence.

RESULTS:

8,265 adults who initiated antiretroviral therapy contributed 29,077 person-years and 123 MI events (65 T1MI, 58 T2MI). Median follow-up time was 2.9 (interquartile range 1.4, 5.1) years. ABC initiators were more likely to have a history of IDU, hepatitis C virus infection, hypertension, diabetes, impaired kidney function, hyperlipidemia, low (<200 cells/mm3) CD4 counts, and a history of AIDS. The risk of the combined MI outcome was greater for persons who used ABC in the prior 6 months (aHR=1.84 [1.17, 2.91]; and persisted for T1MI (aHR=1.62 [1.01,]) and T2MI (aHR=2.11 [1.08, 4.29]). FRS did not modify the effect of ABC on MI (p=0.14) and inclusion of FRS in the MSM did not diminish the effect of recent ABC use on the combined outcome.

CONCLUSIONS:

Recent ABC use was associated with MI after adjustment for known risk factors and for FRS. However, screening for T1MI risks may not identify all or even most persons at risk for ABC use-associated MIs.

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Elion RA

BC Centre for Excellence in HIV/AIDS

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Recent abacavir use increases risk for Types 1 and 2 myocardial infarctions among adults with HIV.

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